====== Transcranial magnetic resonance-guided focused ultrasound ======

{{rss>https://pubmed.ncbi.nlm.nih.gov/rss/search/1XkGOs2RTTP8VMDuS3pnBjXoviJ0XytKrQFrZgzVkgANFC5Ue_/?limit=15&utm_campaign=pubmed-2&fc=20240116173540}}
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[[Transcranial Magnetic Resonance]]-Guided [[Focused Ultrasound]] (tcMRgFUS) typically refers to a therapeutic technique that combines [[magnetic resonance imaging]] (MRI) and [[focused ultrasound]] to treat certain neurological conditions.

===== Breakdown of the components =====

Transcranial: This means the procedure is done through the skull without the need for surgery. The ultrasound waves are targeted at specific brain regions without any incisions.

Magnetic Resonance-Guided (MRg): MRI is used to visualize and guide the procedure in real-time. This provides accurate imaging of the brain and allows for precise targeting of the ultrasound.

[[Focused Ultrasound]] (FUS): This involves the use of high-intensity sound waves that are focused on a specific target within the brain. The focused ultrasound can create thermal or mechanical effects, depending on the application.
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[[Transcranial]] [[magnetic resonance-guided focused ultrasound]] at low intensities has been reported to directly evoke responses and reversibly inhibit function in the central nervous system. While some doubt has been cast on the ability of [[ultrasound]] to directly evoke neuronal responses, spatially-restricted [[transcranial ultrasound]] has demonstrated consistent, inhibitory effects

tFUS predominantly causes neuroinhibition and the primary biophysical mechanism is the thermal effect of [[focused ultrasound]]
((Darrow DP, O'Brien P, Richner TJ, Netoff TI, Ebbini ES. Reversible
neuroinhibition by focused ultrasound is mediated by a thermal mechanism. Brain
Stimul. 2019 Jul 23. pii: S1935-861X(19)30299-2. doi: 10.1016/j.brs.2019.07.015. 
[Epub ahead of print] PubMed PMID: 31377096.
)).
===== Indications =====

see [[Transcranial magnetic resonance-guided focused ultrasound indications]].