A total of 120 patients with [[disc herniation]] surgery were enrolled in a study. The samples were excited during [[discectomy]] and then cultured in both anaerobic and aerobic incubations. Minimum inhibitory concentration (MIC) was performed for determination of [[antibiotic]] susceptibility.

Of 120 samples, 60 (50%) samples were positive for [[microorganism]]s. Disc herniation was at the level of L4-L5 in 63 cases and L5-S1 in 57 cases.

According to the results and presence of P. acnes in more than 35% of the cultured samples, the presence of P. acnes in [[lumbar disc herniation]] is a suspected element leading to this condition. After analysis of the antibiotics, the lowest MIC value was identified for [[amoxicillin]], [[ciprofloxacin]], [[erythromycin]], [[rifampicin]], [[tetracycline]], [[vancomycin]]; the moderate MIC value was for [[fusidic acid]]; and the highest MIC value was for [[gentamicin]] and [[trimethoprim]]
((Salehpour F, Aghazadeh J, Mirzaei F, Ziaeii E, Alavi SAN. Propionibacterium
acnes Infection in Disc Material and Different Antibiotic Susceptibility in
Patients With Lumbar Disc Herniation. Int J Spine Surg. 2019 Apr
30;13(2):146-152. doi: 10.14444/6019. eCollection 2019 Apr. PubMed PMID:
31131213; PubMed Central PMCID: PMC6510207.
)).