Tenascin C (TN-C) is a [[glycoprotein]] that in humans is encoded by the TNC gene.

It is expressed in the [[extracellular matrix]] of various tissues during development, disease, or injury, and in restricted neurogenic areas of the central nervous system.

Tenascin-C is the founding member of the tenascin protein family. In the embryo it is made by migrating cells like the neural crest; it is also abundant in developing tendons, bone, and cartilage.