====== Dysembryoplastic Neuroepithelial Tumor (DNET) - Temporal Lobe ====== ===== Overview ===== **Dysembryoplastic Neuroepithelial Tumor (DNET)** is a benign, WHO grade I glioneuronal tumor typically presenting in children and young adults with **long-standing, pharmacoresistant epilepsy**. The **temporal lobe** is the most common location. ===== Epidemiology ===== * Age: Childhood to young adulthood (most < 20 years) * Slight male predominance * ~80% of cases involve the **temporal lobe** ===== Clinical Presentation ===== * Chronic, intractable **focal epilepsy** * Often normal neurological exam * Rarely causes increased intracranial pressure or neurological deficits ===== Diagnosis ===== [[Dysembryoplastic Neuroepithelial Tumor Diagnosis]]. ===== Treatment ===== * **Surgical resection** is the treatment of choice * **Gross total resection** often cures epilepsy * Recurrence is rare ===== Prognosis ===== * Excellent long-term prognosis * Very low risk of malignant transformation * Seizure freedom in >80% after complete resection ===== Differential Diagnosis ===== * Ganglioglioma * Oligodendroglioma (especially low-grade) * Cortical dysplasia without tumor * Low-grade astrocytoma ===== References ===== * WHO Classification of Tumors of the CNS, 2021 * Guerrini R, et al. Epilepsy surgery and DNETs. Epilepsia. 2012. * Blumcke I, et al. Histopathological findings in long-term epilepsy surgery. Brain Pathol. 2007.