The TAM family of RTKs, consisting of Tyro3, [[Axl]], and MerTK, is prominently expressed during the development and function of the central nervous system (CNS). Aberrant expression and dysregulated activation of TAM family members has been demonstrated in a variety of CNS-related disorders and diseases, including the most common but least treatable brain cancer in children and adults: glioblastoma multiforme
((Pierce AM, Keating AK. TAM receptor tyrosine kinases: expression, disease and 
oncogenesis in the central nervous system. Brain Res. 2014 Jan 13;1542:206-20.
doi: 10.1016/j.brainres.2013.10.049. Epub 2013 Nov 1. Review. PubMed PMID:
24184575; PubMed Central PMCID: PMC4141466.
)).