====== Syndromic Craniosynostosis Etiology ======

In terms of syndromic craniosynostosis not only do [[Fibroblast growth factor receptor 3]] and [[TWIST transcription factor]] feature, but also [[FGFR1]] and in particular [[FGFR2]], which has been reported in 90% of the syndromic craniosynostoses such as Apert, Crouzon, Peiffer and Jackson–Weiss.

The mutations can be divided into mutations that lead to gain of function (in FGFR genes) and mutations that lead to loss of function (in TWIST genes).