====== SW1573 Cell Line ======

The **[[SW1573]]** cell line is derived from a human **non-small cell lung carcinoma (NSCLC)**, specifically an **adenocarcinoma**. It is commonly used in cancer research to investigate drug resistance, tumor progression, and gene expression profiles.

===== Origin =====
  * **Species**: Homo sapiens (Human)
  * **Tissue**: Lung
  * **Disease**: Adenocarcinoma
  * **Histology**: Non-small cell lung cancer (NSCLC)

===== Characteristics =====
  * **Morphology**: Epithelial
  * **Doubling time**: ~24–36 hours
  * **Growth properties**: Adherent
  * **Tumorigenic in mice**: Yes (in immunocompromised mice)
  * **EGFR status**: Wild-type (often used in contrast to mutant EGFR models)

===== Applications =====
  * Study of **chemoresistance**, especially to cisplatin and paclitaxel
  * Research on **apoptosis and cell cycle** regulation
  * Gene expression profiling in NSCLC
  * Used as a comparator cell line in targeted therapy studies

===== Culture Conditions =====
  * **Medium**: RPMI-1640 supplemented with 10% fetal bovine serum (FBS)
  * **Temperature**: 37°C
  * **CO₂**: 5%