====== Supratentorial ependymoma YAP1 fusion-positive ====== [[Supratentorial ependymoma]] [[YAP1]] fusion-positive YAP1 fusion-positive supratentorial ependymomas predominantly occur in infants, but the molecular mechanisms of oncogenesis are unknown. Here we show YAP1-MAMLD1 fusions are sufficient to drive malignant transformation in mice, and the resulting tumors share histo-molecular characteristics of human ependymomas ((https://www.nature.com/articles/s41467-019-11884-5))