====== Sporadic ======


"Sporadic" refers to something that occurs irregularly or infrequently, without a predictable pattern. In medical and scientific contexts, it describes cases or events that happen randomly and are not inherited or related to a known family history or consistent external factor.

For example:

1. **Sporadic Disease**: A disease that arises independently in individuals rather than as a result of genetics or inheritance. In this case, "sporadic" indicates that the condition is not typically passed down through families, unlike hereditary or familial cases.

2. **Sporadic Occurrence**: An event that happens unpredictably and intermittently, rather than continuously or in a clustered fashion.

In the case of "sporadic [[vestibular schwannoma]]," the term suggests that these tumors arise randomly in individuals, without a known genetic cause or familial link, and generally affect only one side. 
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This is in contrast to cases where a genetic predisposition, like [[neurofibromatosis type 2]] (NF2), causes tumors to occur on both sides.
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[[Cerebral cavernous malformation]]s (CCMs) are hemorrhagic [[vascular]] [[disorder]]s with varied clinical and radiological [[presentation]]s, occurring sporadically due to [[MAP3K3]] or [[PIK3CA]] mutations or through inherited germline mutations of CCM genes