====== Somatostatin ====== (also known as [[growth hormone]]-inhibiting hormone (GHIH) or somatotropin release-inhibiting factor (SRIF)) or somatotropin release-inhibiting hormone is a [[peptide hormone]] that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors and inhibition of the release of numerous secondary hormones. Somatostatin inhibits [[insulin]] and [[glucagon]] secretion. Somatostatin treatment can induce extensive fibrosis in [[GH secreting pituitary neuroendocrine tumor]] ((Kerschbaumer J, Pinggera D, Moser P, Hofmann A, Thomé C, Freyschlag CF. Somatostatin treatment can induce extensive fibrosis in growth hormone-producing adenoma. Acta Neurochir (Wien). 2016 Mar;158(3):441-3. doi: 10.1007/s00701-016-2714-7. Epub 2016 Jan 23. PubMed PMID: 26801514. )). ===== Somatostatin receptor ===== see [[somatostatin receptor]]. ===== Somatostatin analogs ===== [[Somatostatin analog]]s