[[Neurofibromatosis type 2]] ([[NF2]]), a multiple [[neoplasia]] [[syndrome]], is a [[manifestation]] of an impaired [[expression]] of the [[merlin]] [[protein]], exerting [[inhibitor]]y effects on cell [[proliferation]] [[signal]]s due to abnormalities of the NF2 gene located on [[chromosome 22]]. About half of patients inherit a [[germline]] [[mutation]] from a parent, and nearly 60% of de novo NF2 patients are estimated to have somatic [[mosaicism]].