====== Sleep quality ======

Sleep is a fundamental homeostatic process, and disorders of sleep can greatly affect the quality of life. 

Unlike [[sleep]] quantity, sleep quality refers to how well you sleep. For adults, good quality sleep means that you typically fall asleep in 30 minutes or less, sleep soundly through the night with no more than one awakening, and drift back to sleep within 20 minutes if you do wake up.
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Shorter actigraphy-assessed sleep time and poorer subjective sleep quality were associated with increased carotid atherosclerosis among midlife women. Associations persisted adjusting for CVD risk factors, hot flashes, and estradiol
((Thurston RC, Chang Y, von Känel R, Barinas-Mitchell E, Jennings JR, Hall MH,
Santoro N, Buysse DJ, Matthews KA. Sleep Characteristics and Carotid
Atherosclerosis Among Midlife Women. Sleep. 2017 Feb 1;40(2). doi:
10.1093/sleep/zsw052. PubMed PMID: 28364498.
)).
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[[Saffron]] supplementation as a treatment for improving [[sleep quality]] have promising clinical application as its great improvement on all efficacy [[outcome]]s and no serious [[adverse event]]s occurred as the dose was increased. The dose of 100 mg saffron supplementation per day was proved to achieve excellent and more stable curative effect on improving sleep quality in a subgroup analysis. However, further [[investigation]] is necessary to confirm the [[efficacy]] and long-term [[safety]] of different doses of saffron for [[insomnia]].
((Lian J, Zhong Y, Li H, Yang S, Wang J, Li X, Zhou X, Chen G. Effects of
saffron supplementation on improving [[sleep quality]]: a meta-analysis of
randomized controlled trials. Sleep Med. 2022 Mar 6;92:24-33. doi:
10.1016/j.sleep.2022.03.001. Epub ahead of print. PMID: 35325766.)).