====== Simvastatin ======

The [[neuroprotection]] effects of simvastatin on the pre-existing [[hypercholesterolemia]] during [[TBI]] in rats may be related to its anti-neuroinflammatory effects but not to its cholesterol-lowing effects
((Chong AJ, Lim SW, Lee YL, Chio CC, Chang CH, Kuo JR, Wang CC. The
Neuroprotective Effects of Simvastatin on High Cholesterol Following Traumatic
Brain Injury in Rats. World Neurosurg. 2019 Dec;132:e99-e108. doi:
10.1016/j.wneu.2019.08.250. Epub 2019 Sep 10. PubMed PMID: 31518751.
)).
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A [[meta-analysis]]
((Vergouwen MD, de Haan RJ, Vermeulen M, et al. Effect of statin treatment on vasospasm, delayed cerebral ischemia, and functional outcome in patients with aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis update. Stroke. 2010; 41:e47–e52))
and multicenter randomized phase 3 trial of [[simvastatin]]
((Kirkpatrick PJ, Turner CL, Smith C, et al. Simvastatin in aneurysmal subarachnoid hemorrhage (STASH): a multicentre randomized phase 3 trial. Lancet Neurol. 2014; 13:666–675)) 
found no clinical benefit for [[aneurysmal subarachnoid hemorrhage]].
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It is a [[statin]] that could attenuate [[cerebral vascular endothelial inflammatory response]] in a rat [[traumatic brain injury]]. 

Simvastatin combined with an antioxidant could provide [[neuroprotection]] and it may be attributed to a dampening of [[cerebral vascular endothelial inflammatory response]].
((Wang KW, Wang HK, Chen HJ, Liliang PC, Liang CL, Tsai YD, Cho CL, Lu K.
Simvastatin combined with antioxidant attenuates the cerebral vascular
endothelial inflammatory response in a rat traumatic brain injury. Biomed Res
Int. 2014;2014:910260. doi: 10.1155/2014/910260. Epub 2014 Jun 11. PubMed PMID:
25013810.)).

===== References =====