====== SHCBP1 ======
SHCBP1, a member of [[Src]] homolog and collagen homolog ([[Shc]]) family, was significantly overexpressed in glioma tissues and glioma cell lines compared to the corresponding normal tissues and cells. Ectopic overexpression of SHCBP1 promoted glioma cell migration and invasion, whereas knockdown of endogenous SHCBP1 had the opposite effects. Importantly, Zhou et al., demonstrated that SHCBP1 promoted aggressiveness in gliomas by activating the [[Nuclear factor kappa]] [[signaling pathway]]. Collectively, the study indicates that SHCBP1 plays a pivotal role to promote progression in gliomas and targeting the oncogenic effects of SHCBP1 may provide a clinical strategy to treat gliomas
((Zhou Y, Tan Z, Chen K, Wu W, Zhu J, Wu G, Cao L, Zhang X, Zeng X, Li J, Zhang 
W. Overexpression of SHCBP1 promotes migration and invasion in gliomas by
activating the NF-κB signaling pathway. Mol Carcinog. 2018 May 10. doi:
10.1002/mc.22834. [Epub ahead of print] PubMed PMID: 29745440.
)).