Only 4 ependymomas of the human sellar region have been reported to date and all have had classic histologic features. Herein, we describe the clinicopathologic features of a sellar, low-grade ependymoma with unusual histology, but classic ultrastructural features, occurring in an elderly patient and thus expanding the spectrum of reported cases. The literature is reviewed and concepts of histogenesis are explored, particularly an origin in "ependymal [[pituicyte]]s." The concept that sellar ependymoma is [[pituicyte]]-derived is explored ((Scheithauer BW, Swearingen B, Whyte ET, Auluck PK, Stemmer-Rachamimov AO. Ependymoma of the sella turcica: a variant of pituicytoma. Hum Pathol. 2009 Mar;40(3):435-40. doi: 10.1016/j.humpath.2008.08.013. Epub 2008 Nov 7. PubMed PMID: 18992914. )).