====== S100B in traumatic brain injury ======

{{rss>https://pubmed.ncbi.nlm.nih.gov/rss/search/1tQjT4yH2iumFpBm63fTgrDmg-uDMGgBLSCwxnyOxjgsXMnEwr/?limit=15&utm_campaign=pubmed-2&fc=20230711115107}}
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Trnka et al. examined the levels of [[S100B]] [[protein]] in 124 [[patient]]s with [[traumatic brain injury]] (TBI).

The [[S100B]] protein level 72 h after [[injury]] and changes over 72 h afterward are [[statistically significant]] for the [[prediction]] of a good clinical [[condition]] 1 month after injury. The highest [[sensitivity]] (81.4%) and [[specificity]] (83.3%) for the S100B protein value after 72 h was obtained for a cut-off value of 0.114. For the change after 72 h, that is a decrease in S100B value, the optimal cut-off is 0.730, where the sum of specificity (76.3%) and sensitivity (54.2%) is the highest, or a decrease by 0.526 at the cut-off value, where sensitivity (62.5%) and specificity (62.9%) are more balanced. The S100B values were the highest at [[baseline]]; the S100B value taken 72 h after [[trauma]] negatively correlated with [[GCS]] upon discharge or transfer (r=-0.517, P<0.0001). They found no relationship between S100B protein and [[hypertension]], [[diabetes mellitus]], [[BMI]], or the season when the trauma occurred. Changes in values and a higher level of S100B protein were demonstrated in polytraumas with a median of 1.070 (0.042; 8.780) μg/L compared to isolated TBI with a median of 0.421 (0.042; 11.230) μg/L.

S100B protein level with specimen collection 72 h after trauma can be used as a complementary marker of patient [[prognosis]]
((Trnka S, Stejskal P, Jablonsky J, Krahulik D, Pohlodek D, Hrabalek L. [[S100B]] [[protein]] as a [[biomarker]] and [[predictor]] in [[traumatic brain injury]]. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2023 Jul 10. doi: 10.5507/bp.2023.025. Epub ahead of print. PMID: 37431619.)).

===== S100B in mild traumatic brain injury =====

see [[S100B in mild traumatic brain injury]].