=====Rosuvastatin=====
Rosuvastatin is a potent [[statin]].

Biochemical, histopathological, ultrastructural analysis and functional tests revealed that rosuvastatin exhibits meaningful [[neuroprotection]] effects against [[spinal cord injury]]
((Kahveci R, Gökçe EC, Gürer B, Gökçe A, Kisa U, Cemil DB, Sargon MF, Kahveci
FO, Aksoy N, Erdoğan B. Neuroprotective effects of rosuvastatin against traumatic
spinal cord injury in rats. Eur J Pharmacol. 2014 Oct 15;741:45-54. doi:
10.1016/j.ejphar.2014.07.042. Epub 2014 Jul 29. PubMed PMID: 25084223.)).

Rosuvastatin pretreatment ameliorates early [[brain injury]] (EBI) after a [[subarachnoid hemorrhage]] (SAH) through the attenuation of [[oxidative stress]] and [[nuclear factor]]-kappa B (NF-κB) mediated [[inflammation]]
((Uekawa K, Hasegawa Y, Ma M, Nakagawa T, Katayama T, Sueta D, Toyama K, Kataoka
K, Koibuchi N, Kawano T, Kuratsu J, Kim-Mitsuyama S. Rosuvastatin ameliorates
early brain injury after subarachnoid hemorrhage via suppression of superoxide
formation and nuclear factor-kappa B activation in rats. J Stroke Cerebrovasc
Dis. 2014 Jul;23(6):1429-39. doi: 10.1016/j.jstrokecerebrovasdis.2013.12.004.
Epub 2014 Feb 12. PubMed PMID: 24529602.
)).

Both topical application and systemic administration of ROS show meaningful preventive effects over epidural fibrosis through multiple mechanisms. The results of a study provide the first experimental evidence of the preventive effects of ROS over [[epidural fibrosis]]
((Gürer B, Kahveci R, Gökçe EC, Ozevren H, Turkoglu E, Gökçe A. Evaluation of
topical application and systemic administration of rosuvastatin in preventing
epidural fibrosis in rats. Spine J. 2015 Mar 1;15(3):522-9. doi:
10.1016/j.spinee.2014.10.018. Epub 2014 Oct 22. PubMed PMID: 25452015.))

Rosuvastatin promoted endothelialization of the coiled [[aneurysm neck]] via induction of [[endothelial progenitor cell]]s (EPCs), suggesting that promoting endothelialization provides an additional therapeutic opportunity during vascular endothelium repair
((Liu P, An Q, Chen X, Huang J, Yang GY, Zhu W. Rosuvastatin for enhancement of 
aneurysm neck endothelialization after coil embolization: promotion of
endothelial progenitor cells in a rodent model. J Neurosurg. 2015 Sep 25:1-10.
[Epub ahead of print] PubMed PMID: 26406802.
))