====== Recurrent seizure ====== [[Recurrent]] means you have a seizure more than once. ===== Risk Factors ===== [[Antiepileptic Drug Withdrawal]] at ≥16 years of [[age]] and a [[diagnosis]] other than [[juvenile myoclonic epilepsy]] may be independent risk factors for [[seizure]] [[recurrence]] after drug withdrawal in [[adolescent]] patients ((Komatsubara T, Kobayashi Y, Hiraiwa A, Magara S, Hojo M, Ono T, Okazaki K, Fukuda M, Tohyama J. [[Recurrence]] [[rate]]s and risk factors for [[seizure]] [[recurrence]] following antiseizure [[medication]] [[withdrawal]] in [[adolescent]] [[patient]]s with [[genetic generalized epilepsy]]. Epilepsia Open. 2022 Apr 21. doi: 10.1002/epi4.12603. Epub ahead of print. PMID: 35445562.)). ===== Prevention ===== [[Pregabalin]] was associated with a relative reduction in [[seizure]] burden in neurocritical ill patients with recurrent [[seizure]]s, especially those with [[cyclic seizure]]s, and may be considered in the therapeutic arsenal for [[refractory]] [[seizure]]s. Whether this effect is mediated via modulation of [[spreading depolarization]] requires further study ((Busl KM, Fong MWK, Newcomer Z, Patel M, Cohen SA, Jadav R, Smith CN, Mitropanopoulos S, Bruzzone M, Hella M, Eisenschenk S, Robinson CP, Roth WH, Ameli PA, Babi MA, Pizzi MA, Gilmore EJ, Hirsch LJ, Maciel CB. [[Pregabalin]] for [[Recurrent Seizure]]s in [[Critical Illness]]: A Promising Adjunctive [[Therapy]], Especially for [[cyclic Seizure]]s. Neurocrit Care. 2022 Feb 25. doi: 10.1007/s12028-022-01459-6. Epub ahead of print. PMID: 35217998.)).