===== 🧪 Real-World Experience ===== The term **real-world experience** refers to clinical observations and outcomes collected **outside of randomized controlled trials (RCTs)**. It emphasizes data obtained from **routine clinical practice**, **registries**, or **observational cohorts**, and provides insights into how interventions perform in **non-ideal, everyday settings**. ==== āœ… Characteristics of Real-World Data ==== * Reflects **heterogeneous patient populations** * Includes **variations in clinician practice** * Captures **long-term outcomes** and **adherence patterns** * May uncover **rare adverse effects** or **unanticipated benefits** ==== 🧩 Role in Evidence-Based Medicine ==== While real-world data may lack the internal validity of RCTs, it contributes to **external validity** and **generalizability**, informing: * Treatment effectiveness in diverse populations * Decision-making in **low-evidence scenarios** * **Post-marketing surveillance** of drugs and devices > āš ļø Real-world experience should complement—not replace—evidence from well-designed trials. ---- **Example Usage:** > "Real-world experience with 7T MRI in DBS reveals variability in protocol standardization and site-specific practices, unlike controlled environments."