====== PTRF in glioma ======

{{rss>https://pubmed.ncbi.nlm.nih.gov/rss/search/1BCB_SEATPONC7tUtCcRLTDsRJy8VXsCaeiSWbAWB0kZTmjobD/?limit=15&utm_campaign=pubmed-2&fc=20230616052036}}
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[[Polymerase]] I and transcript release factor (PTRF) plays a role in the regulation of [[gene expression]] and the release of [[RNA transcript]]s during [[transcription]], which have been associated with various human diseases. However, the role of PTRF in [[glioma]] remains unclear. 

Sun et al. in a study, RNA sequencing (RNA-seq) data (n = 1022 cases) and [[whole-exome sequencing]] (WES) data (n = 286 cases) were used to characterize the PTRF expression features. [[Gene ontology]] (GO) [[functional enrichment analysis]] was used to assess the biological implication of changes in PTRF expression. As a result, the expression of PTRF was associated with malignant progression in gliomas. Meanwhile, somatic mutational profiles and copy number variations (CNV) revealed the glioma subtypes classified by PTRF expression showed distinct genomic alteration. Furthermore, GO functional enrichment analysis suggested that PTRF expression was associated with [[cell migration]] and [[angiogenesis]], particularly during an [[immune response]]. [[Survival analysis]] confirmed that a high expression of PTRF is associated with a poor [[prognosis]]. In summary, PTRF may be a valuable factor for the [[glioma diagnosis]] and treatment target of glioma
((Sun S, Yang C, Wang K, Huang R, Zhang KN, Liu Y, Cao Z, Zhao Z, Jiang T. Molecular and clinical characterization of [[PTRF]] in glioma via 1,022 samples. BMC Cancer. 2023 Jun 16;23(1):551. doi: 10.1186/s12885-023-11001-2. PMID: 37322408.))
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A study highlights that PTRF can act as an independent biomarker to predict the prognosis of GBM patients after TMZ treatment and describes a new mechanism contributing to TMZ-resistance. In addition, this study may provide a novel idea for GBM therapy
((Yang E, Wang L, Jin W, Liu X, Wang Q, Wu Y, Tan Y, Wang Y, Cui X, Zhao J, Tong F, Hong B, Xiao M, Liu X, Fang C, Kang C. PTRF/Cavin-1 enhances chemo-resistance and promotes temozolomide efflux through extracellular vesicles in glioblastoma. Theranostics. 2022 May 16;12(9):4330-4347. doi: 10.7150/thno.71763. PMID: 35673568; PMCID: PMC9169358.))