====== Prophylactic antibiotics for cerebrospinal fluid fistula ======


Prophylactic [[antibiotic]]s are controversial. There was no difference in the [[incidence]] of [[morbidity]] of [[meningitis]] between treated and untreated patients
((Klastersky J, Sadeghi M, Brihaye J. Antimicrobial 2328
Prophylaxis in Patients with Rhinorrhea or Otorrhea: A Double Blind Study. Surg Neurol. 1976; 6:111–114)). 

Furthermore, the risk of selecting resistant strains appears real
((Spetzler RF, Zabramski JM. Cerebrospinal Fluid Fistula. Contemp Neurosurg. 1986; 8:1–7))
and is therefore usually avoided.

[[Prophylactic antibiotics for posttraumatic cerebrospinal fluid fistula]]