====== PPAR agonist ======

1: Li YF, Ren X, Zhang L, Wang YH, Chen T. Microglial polarization in TBI:
Signaling pathways and influencing pharmaceuticals. Front Aging Neurosci. 2022
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2: Liang H, Tang T, Huang H, Li T, Gao C, Han Y, Yuan B, Gao S, Wang H, Zhou ML.
Peroxisome proliferator-activated receptor-γ ameliorates neuronal ferroptosis
after traumatic brain injury in mice by inhibiting cyclooxygenase-2. Exp Neurol.
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3: Meng X, Zhang Y, Li Z, Hu J, Zhang D, Cao W, Li M, Ma G, Wang S, Cui P, Cai
Q, Huang G. A novel natural PPARγ agonist, Gypenoside LXXV, ameliorates
cognitive deficits by enhancing brain glucose uptake via the activation of
Akt/GLUT4 signaling in db/db mice. Phytother Res. 2022 Apr;36(4):1770-1784. doi:
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4: Xie S, Jiang X, Doycheva DM, Shi H, Jin P, Gao L, Liu R, Xiao J, Hu X, Tang
J, Zhang L, Zhang JH. Activation of GPR39 with TC-G 1008 attenuates
neuroinflammation via SIRT1/PGC-1α/Nrf2 pathway post-neonatal hypoxic-ischemic
injury in rats. J Neuroinflammation. 2021 Oct 13;18(1):226. doi:
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5: Li Z, Zhang Y, Zheng Y, Liu W, Zhang X, Li W, Zhang D, Cai Q, Wang S, Meng X,
Huang G. Intranasal 15d-PGJ2 ameliorates brain glucose hypometabolism via PPARγ-
dependent activation of PGC-1α/GLUT4 signalling in APP/PS1 transgenic mice.
Neuropharmacology. 2021 Sep 15;196:108685. doi:
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6: Zhu W, Zhao H, Xu F, Huang B, Dai X, Sun J, Nyalali AMK, Zhang K, Ni S. The
lipid-lowering drug fenofibrate combined with si-HOTAIR can effectively inhibit
the proliferation of gliomas. BMC Cancer. 2021 Jun 3;21(1):664. doi:
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7: Wei ST, Huang YC, Chiang JY, Lin CC, Lin YJ, Shyu WC, Chen HC, Hsieh CH. Gain
of CXCR7 function with mesenchymal stem cell therapy ameliorates experimental
arthritis via enhancing tissue regeneration and immunomodulation. Stem Cell Res
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8: Zhou Y, Wang X, Guo L, Chen L, Zhang M, Chen X, Li J, Zhang L. TRPV1
activation inhibits phenotypic switching and oxidative stress in vascular smooth
muscle cells by upregulating PPARα. Biochem Biophys Res Commun. 2021 Mar
19;545:157-163. doi: 10.1016/j.bbrc.2021.01.072. Epub 2021 Feb 4. PMID:
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9: Hasegawa H, Yatomi K, Mitome-Mishima Y, Miyamoto N, Tanaka R, Oishi H, Arai
H, Hattori N, Urabe T. Pioglitazone Prevents Hemorrhagic Infarction After
Transient Focal Ischemia in Type 2 Diabetes. Neurosci Res. 2021 Sep;170:314-321.
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10: Keledjian K, Tsymbalyuk O, Semick S, Moyer M, Negoita S, Kim K, Ivanova S,
Gerzanich V, Simard JM. The peroxisome proliferator-activated receptor gamma
(PPARγ) agonist, rosiglitazone, ameliorates neurofunctional and
neuroinflammatory abnormalities in a rat model of Gulf War Illness. PLoS One.
2020 Nov 13;15(11):e0242427. doi: 10.1371/journal.pone.0242427. PMID: 33186383;
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11: Gamdzyk M, Doycheva DM, Kang R, Tang H, Travis ZD, Tang J, Zhang JH. GW0742
activates miR-17-5p and inhibits TXNIP/NLRP3-mediated inflammation after
hypoxic-ischaemic injury in rats and in PC12 cells. J Cell Mol Med. 2020
Nov;24(21):12318-12330. doi: 10.1111/jcmm.15698. Epub 2020 Oct 9. PMID:
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12: Zhuang J, Peng Y, Gu C, Chen H, Lin Z, Zhou H, Wu X, Li J, Yu X, Cao Y, Zeng
H, Fu X, Xu C, Huang P, Cao S, Wang C, Yan F, Chen G. Wogonin Accelerates
Hematoma Clearance and Improves Neurological Outcome via the PPAR-γ Pathway
After Intracerebral Hemorrhage. Transl Stroke Res. 2021 Aug;12(4):660-675. doi:
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13: Vogas RS, Pereira MTM, Duarte LS, Carneiro MJ, Farsura AF, Machado JAMM,
Costa IF, TomÉ MRN, Milton FA, Neves FAR, Andreo MA, Lopez BG, Sawaya ACHF,
Pascoal VDB, Pascoal ACRF. Evaluation of the anti-inflammatory potential of
Solidago microglossa (Arnica-brasileira) in vivo and its effects on PPARγ
activity. An Acad Bras Cienc. 2020;92(2):e20191201. doi:
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14: Altinoz MA, Elmaci İ, Hacimuftuoglu A, Ozpinar A, Hacker E, Ozpinar A. PPARδ
and its ligand erucic acid may act anti-tumoral, neuroprotective, and myelin
protective in neuroblastoma, glioblastoma, and Parkinson's disease. Mol Aspects
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15: Metzger JM, Lopez MS, Schmidt JK, Murphy ME, Vemuganti R, Emborg ME. Effects
of Cardiac Sympathetic Neurodegeneration and PPAR<i>γ</i> Activation on Rhesus
Macaque Whole Blood miRNA and mRNA Expression Profiles. Biomed Res Int. 2020 May
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16: Sui X, Yoshioka H, Wakai T, Fukumoto Y, Kinouchi H. Neuroprotective effects
of peroxisome proliferator-activated receptor γ agonist through activation of
Akt and signal transducers and activators of transcription 3 in transient
forebrain ischemia. Neuroreport. 2020 Apr 8;31(6):484-489. doi:
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17: Zhou X, He C, Ren J, Dai C, Stevens SR, Wang Q, Zamler D, Shingu T, Yuan L,
Chandregowda CR, Wang Y, Ravikumar V, Rao AU, Zhou F, Zheng H, Rasband MN, Chen
Y, Lan F, Heimberger AB, Segal BM, Hu J. Mature myelin maintenance requires Qki
to coactivate PPARβ-RXRα-mediated lipid metabolism. J Clin Invest. 2020 May
1;130(5):2220-2236. doi: 10.1172/JCI131800. PMID: 32202512; PMCID: PMC7191000.

18: Zhao JL, Chen YJ, Yu J, Du ZY, Yuan Q, Sun YR, Wu X, Li ZQ, Wu XH, Hu J, Xie
R. ISO-alpha-acids improve the hematoma resolution and prevent peri-hematoma
inflammations by transforming microglia via PPARgamma-CD36 axis in ICH rats. Int
Immunopharmacol. 2020 Jun;83:106396. doi: 10.1016/j.intimp.2020.106396. Epub
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19: Altinoz MA, Ozpinar A, Ozpinar A, Hacker E. Erucic acid, a nutritional
PPARδ-ligand may influence Huntington's disease pathogenesis. Metab Brain Dis.
2020 Jan;35(1):1-9. doi: 10.1007/s11011-019-00500-6. Epub 2019 Oct 17. PMID:
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20: Halstead MR, Geocadin RG. The Medical Management of Cerebral Edema: Past,
Present, and Future Therapies. Neurotherapeutics. 2019 Oct;16(4):1133-1148. doi:
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21: Ren T, Liu J, Ge Y, Zhuo R, Peng L, Liu F, Jin X, Yang L. Chronic
oleoylethanolamide treatment attenuates diabetes-induced mice encephalopathy by
triggering peroxisome proliferator-activated receptor alpha in the hippocampus.
Neurochem Int. 2019 Oct;129:104501. doi: 10.1016/j.neuint.2019.104501. Epub 2019
Jul 9. PMID: 31299417.

22: Yu J, Zheng J, Lu J, Sun Z, Wang Z, Zhang J. AdipoRon Protects Against
Secondary Brain Injury After Intracerebral Hemorrhage via Alleviating
Mitochondrial Dysfunction: Possible Involvement of AdipoR1-AMPK-PGC1α Pathway.
Neurochem Res. 2019 Jul;44(7):1678-1689. doi: 10.1007/s11064-019-02794-5. Epub
2019 Apr 13. PMID: 30982205.

23: Zuo Y, Huang L, Enkhjargal B, Xu W, Umut O, Travis ZD, Zhang G, Tang J, Liu
F, Zhang JH. Activation of retinoid X receptor by bexarotene attenuates
neuroinflammation via PPARγ/SIRT6/FoxO3a pathway after subarachnoid hemorrhage
in rats. J Neuroinflammation. 2019 Feb 21;16(1):47. doi:
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24: Oyefiade A, Erdman L, Goldenberg A, Malkin D, Bouffet E, Taylor MD,
Ramaswamy V, Scantlebury N, Law N, Mabbott DJ. PPAR and GST polymorphisms may
predict changes in intellectual functioning in medulloblastoma survivors. J
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Jan 3. PMID: 30607709.

25: Zhao Y, Wei X, Song J, Zhang M, Huang T, Qin J. Peroxisome Proliferator-
Activated Receptor γ Agonist Rosiglitazone Protects Blood-Brain Barrier
Integrity Following Diffuse Axonal Injury by Decreasing the Levels of
Inflammatory Mediators Through a Caveolin-1-Dependent Pathway. Inflammation.
2019 Jun;42(3):841-856. doi: 10.1007/s10753-018-0940-2. PMID: 30488141.

26: Gamdzyk M, Doycheva DM, Malaguit J, Enkhjargal B, Tang J, Zhang JH. Role of
PPAR-β/δ/miR-17/TXNIP pathway in neuronal apoptosis after neonatal hypoxic-
ischemic injury in rats. Neuropharmacology. 2018 Sep 15;140:150-161. doi:
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27: He J, Liu H, Zhong J, Guo Z, Wu J, Zhang H, Huang Z, Jiang L, Li H, Zhang Z,
Liu L, Wu Y, Qi L, Sun X, Cheng C. Bexarotene protects against neurotoxicity
partially through a PPARγ-dependent mechanism in mice following traumatic brain
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28: Wen L, You W, Wang H, Meng Y, Feng J, Yang X. Polarization of Microglia to
the M2 Phenotype in a Peroxisome Proliferator-Activated Receptor Gamma-Dependent
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29: Ren T, Yang WS, Lin Y, Liu JF, Li Y, Yang LC, Zeng KY, Peng L, Liu YJ, Ye
ZH, Luo XM, Ke YJ, Diao Y, Jin X. A novel PPARα/γ agonist, propane-2-sulfonic
acid octadec-9-enyl-amide, ameliorates insulin resistance and gluconeogenesis in
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10.1016/j.ejphar.2018.02.029. Epub 2018 Feb 22. PMID: 29476879.

30: Liu Y, Shi L, Liu Y, Li P, Jiang G, Gao X, Zhang Y, Jiang C, Zhu W, Han H,
Ju F. Activation of PPARγ mediates icaritin-induced cell cycle arrest and
apoptosis in glioblastoma multiforme. Biomed Pharmacother. 2018 Apr;100:358-366.
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31: Xu J, Lv S, Hou Y, Xu K, Sun D, Zheng Y, Zhang Z, Li X, Li Y, Chi G.
<i>miR-27b</i> promotes type II collagen expression by targetting peroxisome
proliferator-activated receptor-γ2 during rat articular chondrocyte
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32: Kinouchi T, Kitazato KT, Shimada K, Yagi K, Tada Y, Matsushita N, Kurashiki
Y, Satomi J, Sata M, Nagahiro S. Treatment with the PPARγ Agonist Pioglitazone
in the Early Post-ischemia Phase Inhibits Pro-inflammatory Responses and
Promotes Neurogenesis Via the Activation of Innate- and Bone Marrow-Derived Stem
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33: Li Y, Xu L, Zeng K, Xu Z, Suo D, Peng L, Ren T, Sun Z, Yang W, Jin X, Yang
L. Propane-2-sulfonic acid octadec-9-enyl-amide, a novel PPARα/γ dual agonist,
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34: Yuan J, Ge H, Liu W, Zhu H, Chen Y, Zhang X, Yang Y, Yin Y, Chen W, Wu W,
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35: Nishio T, Taura K, Iwaisako K, Koyama Y, Tanabe K, Yamamoto G, Okuda Y,
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36: Haynes HR, White P, Hares KM, Redondo J, Kemp KC, Singleton WGB, Killick-
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37: Xu H, You Z, Wu Z, Zhou L, Shen J, Gu Z. WY14643 Attenuates the Scopolamine-
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38: de la Monte SM, Tong M, Schiano I, Didsbury J. Improved Brain Insulin/IGF
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39: Zhou H, Yang WS, Li Y, Ren T, Peng L, Guo H, Liu JF, Zhou Y, Zhao Y, Yang
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41: Qu B, Ma Y, Yan M, Gong K, Liang F, Deng S, Jiang K, Ma Z, Pan X. Sirtuin1
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43: Ibarra-Lara L, Del Valle-Mondragón L, Soria-Castro E, Torres-Narváez JC,
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44: Liu H, Rose ME, Culver S, Ma X, Dixon CE, Graham SH. Rosiglitazone
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45: Rotondi S, Modarelli A, Oliva MA, Rostomyan L, Sanita P, Ventura L, Daly AF,
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47: Teng Z, Jiang L, Hu Q, He Y, Guo Z, Wu Y, Huang Z, Cao F, Cheng C, Sun X,
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48: Niu HS, Ku PM, Niu CS, Cheng JT, Lee KS. Development of PPAR-agonist GW0742
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49: Yao J, Zheng K, Zhang X. Rosiglitazone exerts neuroprotective effects via
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50: Han D, Wei W, Chen X, Zhang Y, Wang Y, Zhang J, Wang X, Yu T, Hu Q, Liu N,
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51: Ching J, Amiridis S, Stylli SS, Bjorksten AR, Kountouri N, Zheng T, Paradiso
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52: Kim JA, Roy RR, Zhong H, Alaynick WA, Embler E, Jang C, Gomez G, Sonoda T,
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54: Sumiyoshi M, Satomi J, Kitazato KT, Yagi K, Shimada K, Kurashiki Y, Korai M,
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58: Qin H, Tan W, Zhang Z, Bao L, Shen H, Wang F, Xu F, Wang Z.
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61: Chao X, Xiong C, Dong W, Qu Y, Ning W, Liu W, Han F, Ma Y, Wang R, Fei Z,
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