[[Evidence]] has been provided that the [[subiculum]] may play an important role in the generation of [[seizure]]s.[[ Electrostimulation]] at this target has been reported to have [[anticonvulsant]] effects in kindling and [[pilocarpine rat model]]s, while in a clinical study of [[hippocampal deep brain stimulation]] (DBS), contacts closest to the subiculum were associated with a better anticonvulsive effect.

Vázquez-Barrón et al. evaluated the effect of Electrostimulation of the subiculum in patients with refractory [[mesial temporal lobe epilepsy]] (MTLE) who have [[hippocampal sclerosis]] (HS).

Six patients with refractory MTLE and HS, who had [[focal impaired-awareness seizures]] (FIAS) and [[focal to bilateral tonic-clonic seizures]] (FBTCS), had DBS electrodes implanted in the subiculum. During the first month after implantation, all patients were OFF stimulation, then they all completed an open-label follow-up of 24 months ON stimulation. DBS parameters were set at 3 V, 450 µs, 130 Hz, cycling stimulation 1 min ON, 4 min OFF.

There was a mean reduction of 49.16% (±SD 41.65) in total seizure number (FIAS + FBTCS) and a mean reduction of 67.93% (±SD 33.33) in FBTCS at 24 months. FBTCS decreased significantly with respect to baseline, starting from month 2 ON stimulation.

[[Subiculum stimulation]] is effective for FBTCS reduction in patients with [[mesial temporal lobe epilepsy]] (MTLE) and [[hippocampal sclerosis]] (HS), suggesting that the [[subiculum]] mediates the generalization rather than the genesis of mesial temporal lobe seizures. Better results are observed at longer follow-up times
((Vázquez-Barrón D, Cuéllar-Herrera M, Velasco F, Velasco AL. Electrostimulation of Subiculum for the Treatment of Refractory Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis: A 2-Year Follow-Up Study. Stereotact Funct Neurosurg. 2020 Oct 28:1-8. doi: 10.1159/000510295. Epub ahead of print. PMID: 33113540.)).