====== Parkinson's disease case series ======

see [[Deep brain stimulation for Parkinson's disease case series]].
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[[Data]] were acquired during [[resting state]] on 34 [[Parkinson's disease]] patients and 25 controls. The ratio of standard uptake value for [[PET]] images and the [[subthalamic nucleus]] (STN) [[Dynamic functional connectivity]] (FC) maps for [[fMRI]] data were generated. The [[metabolic connectivity]] [[mapping]] (MCM) approach that combines PET and fMRI data was used to evaluate the direction of the connectivity. Results showed that PD patients exhibited both increased [[FDG]] uptake and STN-FC in the [[sensorimotor area]] (PFDR < 0.05). MCM analysis showed higher cortical-STN MCM value in the PD group (F = 6.63, P = 0.013) in the left [[precentral gyrus]]. There was a high spatial overlap between the increased [[glucose metabolism]] and increased STN-FC in the sensorimotor area in PD. The MCM approach further revealed an exaggerated cortical input to the STN in PD, supporting the [[precentral gyrus]] as a target for treatment such as the [[repetitive transcranial magnetic stimulation]]
((Zang Z, Song T, Li J, Nie B, Mei S, Zhang C, Wu T, Zhang Y, Lu J. Simultaneous PET/fMRI revealed increased motor area input to subthalamic nucleus in Parkinson's disease. Cereb Cortex. 2022 Feb 23:bhac059. doi: 10.1093/cercor/bhac059. Epub ahead of print. PMID: 35196709.))