====== Oncolytic ====== The term **oncolytic** refers to the ability to selectively destroy cancer cells. It is most commonly used in the context of: === Oncolytic viruses === Oncolytic viruses are viruses that are engineered or naturally selected to: * Infect and replicate within **tumor cells** * Cause **lysis** (destruction) of those cells * **Spare normal, healthy cells** as much as possible Examples include: * **Talimogene laherparepvec (T-VEC)** – a modified herpes simplex virus, approved for melanoma * **Reovirus**, **adenovirus**, **vaccinia**, and **measles virus** – under clinical investigation for various cancers === Oncolytic therapy === This refers to therapeutic approaches that use oncolytic viruses to: * Directly kill cancer cells * Stimulate the immune system to recognize and attack tumors * Be combined with other treatments such as immunotherapy or chemotherapy === Advantages === * **Targeted tumor destruction** * **Immune activation** * **Synergistic with existing treatments** Oncolytic virotherapy is an emerging and promising area of cancer treatment, especially in clinical research and personalized medicine.