====== Omacetaxine mepesuccinate ======

Porcù et al. demonstrated that [[Annexin A2]] (ANXA2) is a pivotal mediator of the pro-oncogenic features displayed by [[glioblastoma]] (Glioblastoma) tumors, the deadliest adult brain malignancies, being involved in the [[cell]] [[stemness]], [[proliferation]], and [[invasion]], thus negatively impacting patient [[prognosis]]. Based on these results, they hypothesized that compounds able to revert ANXA2-dependent [[transcription]]al features could be exploited as reliable treatments to inhibit Glioblastoma cell aggressiveness by hampering their proliferative and migratory potential. Transcriptional signatures obtained by the modulation of ANXA2 activity/levels were functionally mapped through the [[QUADrATiC]] bioinformatic tool for compound identification. Selected compounds were screened by [[cell proliferation]] and migration assays in primary Glioblastoma cells, and we identified Homoharringtonine (HHT) as a potent inhibitor of Glioblastoma cell motility and [[proliferation]], without affecting their viability. Further molecular characterization of the effects displayed by HHT, confirmed its ability to inhibit a transcriptional program involved in cell migration and invasion. Moreover, they demonstrated that the multiple [[antitumor]]al effects displayed by HHT are correlated to the inhibition of [[PDGFRA]]-dependent intracellular signaling through the impairment of STAT3 and RhoA axes. The results demonstrate that HHT may act as a potent inhibitor of cancer [[cell proliferation]] and [[invasion]] in [[glioblastoma]], by hampering multiple PDGFRα-dependent oncogenic signals transduced through the [[STAT3]] and RhoA intracellular components, finally suggesting its potential transferability for achieving an effective impairment of peculiar Glioblastoma hallmarks
((Porcù E, Maule F, Manfreda L, Mariotto E, Bresolin S, Cani A, Bortolozzi R, Puppa AD, Corallo D, Viola G, Rampazzo E, Persano L. Identification of [[Homoharringtonine]] as a potent inhibitor of glioblastoma cell proliferation and migration. Transl Res. 2022 Jul 1:S1931-5244(22)00151-7. doi: 10.1016/j.trsl.2022.06.017. Epub ahead of print. PMID: 35788055.)).