====== Nutritional status ======


[[Nutrition]]al status is a requirement of the health of a person convinced by the [[diet]], the levels of nutrients contained in the body, and normal metabolic integrity. Normal nutritional status is managed by balancing food consumption and normal utilization of nutrients.
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107 subjects (median 78 (IQR 58.5-90.5, range 35-105) yo) were recruited, and factors associated with antibody titer after the third mRNA COVID-19 vaccine were analyzed between 49 elderly (age ≥80, median 94 (IQR 86-97, range 80-105) yo) and 58 younger (≤79, median 61 (IQR 46-71, range 35-79) yo) adults.

Results: Among BMI categories, the underweight group in elderly adults had a lower antibody titer compared to the normal weight group (p < 0.01 after one, three and five months). Elderly adults were less likely to maintain effective antibody titer (≥4,160 AU/ml) compared to younger adults; 76% vs 98%, p < 0.001 after one month, and 45% vs 78%, p < 0.001 after three months. Elderly adults who maintained effective antibody titer for five months had a higher BMI (22.9 kg/m2 vs 20.1 kg/m2, p = 0.02), and were less likely to have underweight BMI (0% vs 31%, p = 0.02) compared to the subjects who failed its maintenance.

These highlight the impact of nutritional status, and the deleterious effect of being underweight [[BMI]] on [[antibody titer]] and its maintenance among elderly adults following booster mRNA COVID-19 vaccine
((Mori M, Doi T, Murata M, Moriyama Y, Akino K, Moriyama T, Maekawa T, Doi N. Impact of nutritional status on antibody titer after booster mRNA COVID-19 vaccine among elderly adults in Japan. J Infect Dis. 2023 Nov 14:jiad495. doi: 10.1093/infdis/jiad495. Epub ahead of print. PMID: 37962870.))