====== Non-small cell lung cancer ======

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Non-[[small-cell lung cancer]] (NSCLC) is any type of epithelial [[lung cancer]] other than [[Small-cell lung cancer]] (SCLC). 

Includes: adenocarcinoma (the most common NSCLC), large cell, squamous cell, bronchoalveolar.

[[Lung cancer]] continues to be a leading cause of cancer-related death worldwide, with [[non-Small-cell lung cancer]] (NSCLC) accounting for more than 80% of lung cancer cases.

===== Epidemiology =====
[[Lung cancer]] is the leading cause of cancer mortality worldwide, accounting for 1.38 million annual deaths, representing 18.2% of total deaths from [[cancer]] 
((Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer
statistics. CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90. doi: 10.3322/caac.20107. 
Epub 2011 Feb 4. Erratum in: CA Cancer J Clin. 2011 Mar-Apr;61(2):134. PubMed
PMID: 21296855.
)).

[[Non-Small-cell lung cancer]] (NSCLC) account for more than 80% of lung cancer cases.

Among those, approximately 7.4% of [[non-Small-cell lung cancer]] (NSCLC) patients will have brain metastases (BM) at presentation
((Schuette W. Treatment of brain metastases from lung cancer: chemotherapy. Lung
Cancer. 2004 Aug;45 Suppl 2:S253-7. Review. PubMed PMID: 15552807.
))
, and between 20–40% of [[Non-Small-cell lung cancer]] (NSCLC) patients will develop [[intracranial metastases]] 
((Brower JV, Robins HI. Erlotinib for the treatment of brain metastases in
non-Small-cell lung cancer. Expert Opin Pharmacother. 2016;17(7):1013-21. doi:
10.1517/14656566.2016.1165206. Epub 2016 Mar 30. Review. PubMed PMID: 26967582.
))
((Zhao J, Chen M, Zhong W, Zhang L, Li L, Xiao Y, Nie L, Hu P, Wang M.
Cerebrospinal fluid concentrations of gefitinib in patients with lung
adenocarcinoma. Clin Lung Cancer. 2013 Mar;14(2):188-93. doi:
10.1016/j.cllc.2012.06.004. Epub 2012 Jul 28. PubMed PMID: 22846582.
)).

===== Classification =====

see [[Non-Small-cell lung cancer classification]].

===== Diagnosis =====

[[Non-Small-cell lung cancer Diagnosis]].

===== Complications =====

==== Non-Small-cell lung cancer metastases ====

[[Non-Small cell lung cancer metastases]]




===== Treatment =====
see [[Non-Small cell lung cancer treatment]].

===== Outcome =====
see [[Non-Small cell lung cancer outcome]].

===== Case series =====
[[Non-Small-cell lung cancer case series]].