====== Nitroglycerin ======
Nitroglycerin (also known as glyceryl trinitrate (GTN)), a vasodilator best known for treatment of ischemic heart disease, has also been investigated for its potential therapeutic benefit in [[ischemic stroke]].


Raises [[ICP]] (less than with [[nitroprusside]] due to preferential venous action)
((Cottrell JE, Patel K, Turndorf H, Ransohoff J. Intracranial pressure changes
induced by sodium nitroprusside in patients with intracranial mass lesions. J
Neurosurg. 1978 Mar;48(3):329-31. PubMed PMID: 632856.
)).

This agent produces a rapid, controllable, but not precipitous fall in blood pressure without rebound, is non-toxic, may not alter cerebrovascular autoregulation, and does not raise intracranial pressure
((Chestnut JS, Albin MS, Gonzalez-Abola E, Newfield P, Maroon JC. Clinical
evaluation of intravenous nitroglycerin for neurosurgery. J Neurosurg. 1978
May;48(5):704-11. PubMed PMID: 417150.
)).

===== Dosage =====
5 mcg/min

Increase by 5 mcg/min q3-5min up to 20 mcg/min, THEN 

Increase by 10 mcg/min

May later increase by 20 mcg/min

Higher dosages required for PVC admin sets

Uninterrupted infusion >24 hours produces tolerance