====== Nitric oxide synthase ======
[[Nitric oxide]] synthases (NOSs) are a family of [[enzyme]]s catalyzing the production of [[nitric oxide]] (NO) from L-arginine. NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural development. It may function as a retrograde neurotransmitter. Nitric oxide is mediated in mammals by the calcium-calmodulin controlled isoenzymes eNOS (endothelial NOS) and nNOS (neuronal NOS). The inducible isoform, iNOS, is involved in immune response, binds calmodulin at physiologically relevant concentrations, and produces NO as an immune defense mechanism, as NO is a free radical with an unpaired electron. It is the proximate cause of septic shock and may function in autoimmune disease.
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see [[Nitric oxide synthase Inhibitor]]

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[[Traumatic brain injury]] (TBI) leads to important and deleterious [[neuroinflammation]], as evidenced by indicators such as [[edema]], [[cytokine]] production, induction of nitric oxide synthase, and leukocyte infiltration.