=====Neurogenic region (NR)===== New neurons are continually born throughout adulthood predominantly in several regions of the brain: The [[subventricular zone]] (SVZ) [[Striatal interneuron]]s The subgranular zone (SGZ), part of the [[dentate gyrus]] of [[hippocampus]]. The [[nucleus accumbens]], specifically medium spiny neurons [[Glioblastoma]] GBM contrast-enhancing recurrence is significantly associated with proximity to NRs. NR-contacting initial tumors were more likely to recur out of radiation treatment fields ((Chen L, Chaichana KL, Kleinberg L, Ye X, Quinones-Hinojosa A, Redmond K. Glioblastoma recurrence patterns near neural stem cell regions. Radiother Oncol. 2015 Aug 11. pii: S0167-8140(15)00392-8. doi: 10.1016/j.radonc.2015.07.032. [Epub ahead of print] PubMed PMID: 26276527. )).