=====Monoamine oxidase B=====
[[Monoamine oxidase]] B (MAOB) is highly expressed in [[glioblastoma]] cell mitochondria, and mitochondrial function is intimately tied to treatment-resistant glioblastoma progression. These glioblastoma properties provide a strong rationale for pursuing a MAOB-selective pro-drug treatment approach that, upon drug activation, targets glioblastoma mitochondria, especially mitochondrial DNA. MP-MUS is the lead compound in a family of pro-drugs designed to treat GBM that is converted into the mature, mitochondria-targeting drug, P(+)-MUS, by MAOB. 

Sharpe et al., show that MP-MUS can successfully kill primary gliomas in vitro and in vivo mouse xenograft models.