====== miR 5188 ======

The biological effect and molecular mechanism of [[miR]]-5188 have not been thoroughly investigated. 

A study elucidated the role of miR-5188 in [[glioma progression]]. Human [[glioma cell line]]s and tissues were used for functional and expression analysis. Cellular and molecular techniques were performed to explore the functions and mechanisms of miR-5188 in glioma. In the [[investigation]], they demonstrated that miR-5188 promoted [[cell proliferation]], the [[G1]]/S transition of the [[cell cycle]], [[migration]] and invasion in glioma and reduced the lifespan of glioma-bearing mice. miR-5188 directly targeted [[FOXO1]] and activated [[PI3K]]/[[AKT]]-[[c-JUN]] signalling, which enhanced miR-5188 expression. Moreover, the c-JUN transcription factor functionally bound to the miR-5188 promoter region, forming the positive feedback loop. The feedback loop promoted glioma progression through activating the PI3K/AKT signalling, and this loop is augmented by the interaction between [[SP1]] and c-JUN. Moreover, it was also found that the miR-5188/FOXO1 axis is facilitated by SP1-activated PI3K/AKT/c-JUN signalling. In glioma samples, miR-5188 expression was found to be an unfavourable factor and was positively associated with the [[mRNA]] levels of SP1 and c-JUN, whereas negatively associated with the mRNA levels of FOXO1. The investigation demonstrates that miR-5188 could function as a tumour promoter by directly targeting FOXO1 and participating in SP1-mediated promotion of cell growth and [[tumorigenesis]] in [[glioma]]
((Yi R, Yang S, Lin X, et al. miR-5188 augments glioma growth, migration and invasion through an SP1-modulated FOXO1-PI3K/AKT-c-JUN-positive feedback circuit [published online ahead of print, 2020 Sep 9]. J Cell Mol Med. 2020;10.1111/jcmm.15794. doi:10.1111/jcmm.15794)).