=====miR 199=====

During the last decade, experimental evidence has demonstrated an important role of hypoxia, which leads to neuronal cell death and angiogenesis, in the mechanisms of seizure precipitation and recurrence. MicroRNA-199 targets hypoxia-inducible factor-1alpha (HIF-1α), which has recently been implicated in the pathophysiology of the hypoxic state and brain injury. However, little is known about the roles of MicroRNA-199 and HIF-1α in the human epileptogenic process.

Data suggest that the abnormal expression of miR-199 and HIF-1α in epileptic brain tissue may be involved in the pathophysiology of human epilepsy and that the expression of HIF-1α may be regulated by miR-199. These findings may provide new insights into the treatment of epilepsy
((Jiang G, Zhou R, He X, Shi Z, Huang M, Yu J, Wang X. Expression levels of
microRNA-199 and hypoxia-inducible factor-1 alpha in brain tissue of patients
with intractable epilepsy. Int J Neurosci. 2016 Apr;126(4):326-34. doi:
10.3109/00207454.2014.994209. Epub 2015 Sep 30. PubMed PMID: 25539181.
)).