[[Circular RNA]]s are involved in [[EGFR]]-TKI resistance, while the role of hsa_circ_0005576 in the [[osimertinib resistance]] of LUAD remain unknown. In a study, Liu et al. demonstrated that hsa_circ_0005576 could facilitate the osimertinib-resistant LUAD cells. Briefly, knockdown of hsa_circ_0005576 not only suppressed the proliferation and promoted the [[apoptosis]] of resistant LUAD cells, but also increased its [[sensitivity]] to osimertinib. Mechanistically, hsa_circ_0005576, serving as a miRNA-sponge, could directly interact with miR-512-5p and subsequently upregulate the miR-512-5p-targeted insulin-like growth factor 1 receptor (IGF1R). The rescue assays indicated that [[miR-512-5p]] inhibition could reverse the effects of hsa_circ_0005576 knockdown on LUAD cells resistance to osimertinib. Overall, the study revealed that hsa_circ_0005576 regulates proliferation and apoptosis through miR-512-5p/IGF1R signaling, further which contributes to resistance of LUAD cells to osimertinib. Meanwhile, it provides a novel insight on the mechanism underlying osimertinib resistance of LUAD
((Liu S, Jiang Z, Xiao P, Li X, Chen Y, Tang H, Chai Y, Liu Y, Zhu Z, Xie Q, He W, Ma Y, Jin L, Feng W. Hsa_circ_0005576 promotes the osimertinib resistance through miR-512-5p/IGF1R axis in lung adenocarcinoma cells. Cancer Sci. 2021 Oct 27. doi: 10.1111/cas.15177. Epub ahead of print. PMID: 34706132.)).