====== Mesial Temporal Sclerosis Diagnosis ====== The diagnosis of mesial temporal sclerosis includes detailed history and physical examination. A history of a prolonged seizure with fever in early life can be a risk factor for development of MTS. ===== MRI ===== see [[Mesial Temporal Sclerosis MRI]]. ===Nuclear medicine=== SPECT and PET imaging are also a useful adjuncts, with both ictal and inter-ictal scans demonstrating abnormalities ictal scan: hyper perfusion interictal scan: hypo perfusion Other causes of temporal lobe epilepsy (TLE) should be considered, especially as small temproal lobe cortical tumours can have similar appearances.