=====Mesencephalic astrocyte derived neurotrophic factor=====
Mesencephalic [[astrocyte derived neurotrophic factor]] (MANF) is a 20kDa human protein which has both [[neuroprotection]] and [[neurorestoration]] activity on [[dopaminergic neuron]]s and therefore may have application for the treatment of [[Parkinson's Disease]]. 

The aim of a study were to determine the translational potential of [[convection-enhanced delivery]] (CED) of MANF for the treatment of PD by studying its distribution in porcine putamen and substantia nigra and to correlate histological distribution with co-infused gadolinium-DTPA using real-time magnetic resonance imaging. Barua et al. describe the distribution of MANF in porcine putamen and substantia nigra using an implantable CED catheter system using co-infused gadolinium-DTPA to allow real-time MRI tracking of infusate distribution. The distribution of gadolinium-DTPA on MRI correlated well with immunohistochemical analysis of MANF distribution. Volumetric analysis of MANF IHC staining indicated a volume of infusion (Vi) to volume of distribution (Vd) ratio of 3 in putamen and 2 in substantia nigra. This study confirms the translational potential of CED of MANF as a novel treatment strategy in PD and also supports the co-infusion of gadolinium as a proxy measure of MANF distribution in future clinical studies. Further study is required to determine the optimum infusion regime, flow rate and frequency of infusions in human trials
((Barua NU, Bienemann AS, Woolley M, Wyatt MJ, Johnson D, Lewis O, Irving C,
Pritchard G, Gill S. Convection-enhanced delivery of MANF - Volume of
distribution analysis in porcine putamen and substantia nigra. J Neurol Sci. 2015
Aug 6. pii: S0022-510X(15)00477-3. doi: 10.1016/j.jns.2015.08.003. [Epub ahead of
print] PubMed PMID: 26276514.
)).

====Member====
[[Conserved dopamine neurotrophic factor]]