[[Rett syndrome]] was first described by Austrian pediatrician Andreas Rett in 1966. Huda Zoghbi demonstrated in 1999 that Rett syndrome is caused by mutations in the gene [[MECP2]], a protein involved in [[chromatin remodeling]] and modulation of [[RNA splicing]]
((Chahrour M, Zoghbi HY. The story of Rett syndrome: from clinic to neurobiology. Neuron. 2007;56(3):422–437. )).