Dr. Bernstein is Professor of Surgery at the University of Toronto and a neurosurgeon at Toronto Western Hospital, University Health Network.

His main areas of interest are neuro-oncology, bioethics, palliative care, and advancing surgery in the developing world, where he spends time operating and teaching. He is a committed educator and has won numerous teaching awards. In 2003 he completed a Masters of Health Science in Bioethics. In 2011 he was awarded the Greg Wilkins-Barrick Chair in International Surgery.

Besides over 350 biomedical papers and chapters published, a book on brain tumours, and a book on bioethics, he has published about 150 popular articles many of which attempt to bridge the gap between the medical profession and the public.
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[[Ahmed Ammar]] and [[Mark Bernstein]] (eds): Neurosurgical [[ethics]] in practice: value-based medicine : [[Springer]]-Verlag, 2014 (ISBN 9783642549793).