====== MAPK3 ======

[[Mitogen activated protein kinase]] 3, also known as p44MAPK and ERK1, is an enzyme that in humans is encoded by the MAPK3 gene.
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The convergence of multi-signals on the [[Erk1]]/2 signaling pathway indicated the vital role of Erk1/2 in the pathogenic processes of [[craniosynostosis]]. Over the past years, researchers tried to interfere the processes of [[suture]] [[fusion]] via molecule mechanisms, especially FGFs and related signaling
((Shukla V, Coumoul X, Wang RH. et al. RNA interference and inhibition of MEK-ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis. Nat Genet. 2007;39:1145–50.))
((Morita J, Nakamura M, Kobayashi Y. et al. Soluble form of [[FGFR2]] with S252W partially prevents craniosynostosis of the apert mouse model. Dev Dynam. 2014;243:560–7.))
((Yin L, Du X, Li CL. et al. A Pro253Arg mutation in fibroblast growth factor receptor 2 (Fgfr2) causes skeleton malformation mimicking human Apert syndrome by affecting both chondrogenesis and osteogenesis. Bone. 2008;42:631–43.))