[[Lectin]]-like oxidized low-density [[lipoprotein]] receptor-1 ([[LOX-1]]), a member of the [[scavenger receptor]] family, recognizes multiple [[ligand]]s and participates in several [[inflammatory]] responses, but its function within the central nervous system (CNS) remains unclear. 

In a study, Ge et al., discovered an increased LOX-1 expression in activated [[microglia]] in vivo and in vitro. Employing the specific inhibitors, they found that conditioned medium of necrotic neurons (Necrotic-CM) induced microglial LOX-1 expression through the MAPKs/NF-κB pathway. Silencing LOX-1 inhibited MAPK phosphorylation, NF-κB-p65 nuclear transportation, and pro-inflammatory factor production in microglia exposed to Necrotic-CM. Furthermore, utilizing the conditioned medium of activated microglia (MG-CM), we discovered microglial LOX-1 aggravated the neuroinflammation-induced neuronal apoptosis. Collectively, a LOX-1/MPAKs/NF-κB positive loop might promote microglia activation and drive the vicious cycle of [[neuroinflammation]] and neuronal injury
((Ge X, Zhang DM, Li MM, Zhang Y, Zhu XY, Zhou Y, Peng X, Shen AG. Microglial
LOX-1/MAPKs/NF-κB positive loop promotes the vicious cycle of neuroinflammation
and neural injury. Int Immunopharmacol. 2019 Feb 23;70:187-200. doi:
10.1016/j.intimp.2019.02.013. [Epub ahead of print] PubMed PMID: 30807932.
)).