Although [[low back pain]] [[pathogenesis]] is very heterogenic, intervertebral disc degeneration (IVD) is commonly regarded as a cornerstone of the cascade of phenomena that produce [[lumbar degenerative spondylosis]] (LDS). It is estimated that the majority of the population is supposed to experience LBP at some point in their lives. The 1-year incidence of the first-ever LBP episode varies from 6.3 to 15.4%, while the 1-year incidence of any LBP episode varies from 1.5 to 36%, with episode remission at 1 year ranging from 54 to 90%
((Hoy D, Brooks P, Blyth F, Buchbinder R. The Epidemiology of low back pain. Best Pract Res Clin Rheumatol. 2010 Dec;24(6):769-81. doi: 10.1016/j.berh.2010.10.002. PMID: 21665125.))