A close monitoring of [[liver function tests]] is recommended during treatment with [[temozolomide]]
((Grieco A, Tafuri MA, Biolato M, Diletto B, Di Napoli N, Balducci N, Vecchio FM, Miele L. Severe cholestatic hepatitis due to temozolomide: an adverse drug effect to keep in mind. Case report and review of literature. Medicine (Baltimore). 2015 Mar;94(12):e476. doi: 10.1097/MD.0000000000000476. PMID: 25816026; PMCID: PMC4554001.))
((Niewald M, Berdel C, Fleckenstein J, Licht N, Ketter R, Rübe C. Toxicity after radiochemotherapy for glioblastoma using temozolomide--a retrospective evaluation. Radiat Oncol. 2011 Oct 21;6:141. doi: 10.1186/1748-717X-6-141. PMID: 22017800; PMCID: PMC3213071.))
((Goldbecker A, Tryc AB, Raab P, Worthmann H, Herrmann J, Weissenborn K. Hepatic encephalopathy after treatment with temozolomide. J Neurooncol. 2011 May;103(1):163-6. doi: 10.1007/s11060-010-0354-y. Epub 2010 Aug 22. PMID: 20730617.))