====== Limbic Tumor of the Temporal Lobe ======

===== Classification =====

see [[Schramm classification]].
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[[Limbic tumor]]s are categorized according to [[Yaşargil]]'s [[classification]] into:

(1) [[Temporal mediobasal tumor]].

(2) insular-temporo-opercular (I-TO) (see [[Insuloopercular glioma]])

(3) fronto-orbital-insular-temporopolar (FO-I-TP).

A total of 50 cases with a mean age at diagnosis of 38 ± 19.9 years (14 women, 36 men) were included. Pathologic diagnoses were as follows: 20 [[anaplastic astrocytoma]]s, 11 [[ganglioglioma]]s, 8 [[astrocytoma]]s (World Health Organization grade II), 3 [[pilocytic astrocytoma]]s, 2 [[dysembryoplastic neuroepithelial tumor]]s, 2 [[oligodendroglioma]]s (grade II), 2 [[anaplastic oligodendroglioma]]s, 1 low-grade glioneuronal tumor, and 1 atypical extraventricular neurocytoma. In all, 36 tumors were limbic and displayed consistent growth patterns (16 mbT, 11 I-TO, 8 FO-I-TP, and 1 pantemporal) and 14 were extralimbic. There were no differences between limbic and extralimbic tumors with regard to age, sex, pathologic diagnosis, and presentation with [[seizure]]s. mbT tumors had more frequent neuronal differentiation (50 %) than I-TO (0 %) and FO-I-TP (25 %) tumors (chi-square = 7.8, df = 2, p = 0.02). Neuronal differentiation correlated with lower grade (r = 0.52, p < 0.01) and younger age (r = 0.52, p < 0.01).

Limbic tumors displayed consistent growth routes. mbT limbic tumors had more frequent neuronal differentiation, which may result from proximity to the neurogenic subgranular zone of the [[hippocampus]]. Neuronal differentiation was maximal in mbT and lowest in I-TO and FO-I-TP tumors and correlated with lower tumor grade and younger age at diagnosis
((Capizzano AA, Kirby P, Moritani T. Limbic Tumors of the Temporal Lobe:
Radiologic-Pathologic Correlation. Clin Neuroradiol. 2014 Jan 29. [Epub ahead of 
print] PubMed PMID: 24474261.
)).