====== LIFEx ======

https://lifexsoft.org/ 

A retrospective study of surgically treated [[glioblastoma]]s between March 2018 and November 2019 was performed. Patients with [[IOUS]] [[B-mode]] and [[strain elastography]] was included. After preprocessing, segmentation and extraction of [[radiomics]] were performed with [[LIFEx]] software. An evaluation of semantic segmentation was carried out using the [[Dice similarity coefficient]] (DSC). Using univariate correlations, radiomic features associated with OS were selected. Subsequently, survival analysis was conducted using Cox univariate regression and Kaplan-Meier curves.

Sixteen patients were available for analysis. The DSC revealed excellent agreement for the segmentation of the tumour region. Of the 52 radiomic features, two texture features from B-mode (conventional mean and the grey-level zone length matrix/short-zone low grey-level emphasis [GLZLM_SZLGE]) and one texture feature from strain elastography (grey-level zone length matrix/long-zone high grey-level emphasis [GLZLM_LZHGE]) were significantly associated with OS. After establishing a cut-off point of the statistically significant radiomic features, we allocated patients in high- and low-risk groups. Kaplan-Meier curves revealed significant differences in OS.

IOUS-based quantitative texture analysis in [[glioblastoma]]s is feasible. Radiomic tumor region characteristics in B-mode and elastography appear to be significantly associated with OS
((Cepeda S, García-García S, Arrese I, Velasco-Casares M, Sarabia R. Relationship between the overall survival in glioblastomas and the radiomic features of intraoperative ultrasound: a feasibility study. J Ultrasound. 2021 Feb 16. doi: 10.1007/s40477-021-00569-9. Epub ahead of print. PMID: 33594589.)).