====== LAT1 ======

LAT1 is a heterodimeric membrane transport protein that preferentially transports branched-chain (valine, leucine, isoleucine) and aromatic (tryptophan, tyrosine) amino acids.

LAT is highly expressed in brain capillaries (which form the blood–brain barrier) relative to other tissues.

A functional LAT1 transporter is composed of two proteins encoded by two distinct genes:

4F2hc/CD98 heavy subunit protein encoded by the SLC3A2 gene.
CD98 light subunit protein encoded by the SLC7A5 gene.
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The overexpression of [[LAT1]] transports in [[brain metastases]] make [[intracranial metastases]] a compelling target for [[amino acid]] [[PET]] [[imaging]]
((Papin-Michault C, Bonnetaud C, Dufour M, et al. Study of LAT1 Expression in Brain
Metastases: Towards a Better Understanding of the Results of Positron Emission
Tomography Using Amino Acid Tracers. PloS one. 2016; 11(6):e0157139.)).