====== Isoliquiritigenin ======

Isoliquiritigenin (ISL, 10 mg/kg) is a bioactive [[flavonoid]] compound with protective effects against [[inflammation]], [[neurodegeneration]], [[cancer]], and [[diabetes]].

Niemann Pick C1 Like 1 (NPC1L1) is a specific transporter of cholesterol uptake. In this study, we found for the first time that ISL downregulates NPC1L1 expression and competitively inhibits cellular cholesterol uptake by binding to NPC1L1 in a concentration-dependent manner in vitro. This study provides a theoretical basis for further investigation of the molecular mechanisms of its cholesterol-lowering effect in vivo and inspired emerging drug research for cholesterol-lowering purposes through NPC1L1 inhibition
((Zeng J, Liu W, Liang B, Shi L, Yang S, Meng J, Chang J, Hu X, Zhang R, Xing D. Inhibitory Effect of Isoliquiritigenin in Niemann-Pick C1-Like 1-Mediated Cholesterol Uptake. Molecules. 2022 Nov 3;27(21):7494. doi: 10.3390/molecules27217494. PMID: 36364321; PMCID: PMC9654431.))

===== Neurosurgery =====

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In a study, the aim was to find out the Artemisia argyi (AA) and Ohwia caudata (OC) leaf extract combination with Isoliquiritigenin in potentiating and complementing effect against chemo drug side effects to ameliorate cardiac damage and improve the cardiac function. In this study, they showed that a combination of low (AA 300 mg/kg; OC 100 mg/kg) and high-dose(AA 600 mg/kg; OC 300 mg/kg) AA and OC water extract with ISL activated the cell survival-related [[AKT]]/[[PI3K]] [[signaling pathway]] in DOX-treated cardiac tissue leading to the upregulation of the antioxidant markers SOD, HO-1, and Keap-1 and regulated mitochondrial dysfunction through the [[Nrf2]] signaling pathway. Moreover, the water extract of AA and OC with ISL inhibited the inflammatory response genes [[IL-6]] and [[IL-1]]β, possibly through the [[NFκB]]/AKT/PI3K/p38α/NRLP3 signaling pathways. The water extract of AA and OC with ISL could be a potential herbal drug treatment for cardiac [[hypertrophy]], inflammatory disease, and [[apoptosis]], which can lead to sudden [[heart failure]]
((Yuan Hsieh DJ, Islam MN, Kuo WW, Shibu MA, Lai CH, Lin PY, Lin SZ, Chen MY, Huang CY. A combination of isoliquiritigenin with Artemisia argyi and Ohwia caudata water extracts attenuates [[oxidative stress]], [[inflammation]], and [[apoptosis]] by modulating Nrf2/Ho-1 [[signaling pathway]]s in SD rats with [[doxorubicin]]-induced acute cardiotoxicity. Environ Toxicol. 2023 Sep 4. doi: 10.1002/tox.23936. Epub ahead of print. PMID: 37661764.)).