====== Introduction ======

The introduction justifies the [[study]] and describes the [[objective]]s. It identifies current knowledge gaps and anticipates how the study results may close those gaps. The [[methodology]] used and the diagnostic hypothesis should also be described in this section. The hypothesis or superiority trial represents the objective of the study to reject the [[null hypothesis]] (x = y) in favor of the alternative hypothesis (x is different from y).

In the introductory section of the [[manuscript]], the [[reviewer]] will immediately develop an idea of the clinical [[question]] of the study to be validated. The introduction justifies the study and describes the objectives. It identifies current knowledge gaps and anticipates how the study results may close those gaps.