====== Intracranial ependymoma classification ======

see [[Ependymoma classification]].
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[[Supratentorial ependymoma]]

[[Infratentorial ependymoma]].

[[Intraventricular ependymoma]]

There are two principal histological subtypes, namely classic (∼70%) and [[anaplastic ependymoma]] (∼30%).
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[[Subependymoma]] 9383/1 WHO grade I

[[Myxopapillary ependymoma]] 9394/1 WHO grade I

[[Ependymoma]]

--[[Papillary ependymoma]] 9393/3 (WHO grade II)

--[[Clear cell ependymoma]] 9391/3 (WHO grade II)

--[[Tanycytic ependymoma]] 9391/3

[[Ependymoma RELA fusion positive]] 9396/3

[[Anaplastic ependymoma]] 9392/3 (WHO grade III).
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===== Molecular subgroup classification =====

Increasingly, as is the case with many other tumors, molecular classification is proving to be more important than histological classification in predicting treatment response and prognosis. Intracranial ependymomas can be divided into four main groups that correlate largely with location:

==== Infratentorial ====
        
[[Posterior fossa type A ependymoma]]: H3 K27 trimethylation

[[Posterior fossa type B ependymoma]]        
    
==== Supratentorial ====
        
RELA fusion (discussed separately)
        
[[YAP1]] fusion.

[[Classification]] into molecular [[ependymoma]] subgroups has been established, but the mechanisms underlying the aggressiveness of certain subtypes remain widely enigmatic.

Of nine ependymoma molecular groups detected by [[DNA methylation]] profiling, the posterior fossa type A (PFA) is most prevalent.