====== Intervertebral disc degeneration treatment ======

{{rss>https://pubmed.ncbi.nlm.nih.gov/rss/search/1-WjP5N_oaMKcrfSr9c-k2WjAzRCaj5NYwdSL9ts6DrtcG69lT/?limit=15&utm_campaign=pubmed-2&fc=20230330025616}}
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Conservative therapies and surgical treatments for [[Intervertebral disc degeneration]] provide only symptomatic [[pain]] [[relief]] without promoting [[intervertebral disc regeneration]]. Therefore, the clinical demand for disc regenerative therapies for [[intervertebral disc repair]] is high.

There are several treatment options available, including:

[[Physical therapy]]: Physical therapy can help strengthen the muscles that support the spine and improve flexibility. It can also teach patients proper posture and body mechanics to reduce strain on the discs.

[[Pain]] [[medication]]s: Over-the-counter pain medications like ibuprofen or acetaminophen can help manage mild to moderate pain. In some cases, prescription pain medications or muscle relaxants may be necessary.

[[Steroid injection]]s: Steroid injections can be used to reduce inflammation and pain in the affected area. These injections are typically administered by a pain management specialist.

Surgery: In severe cases where conservative treatments have failed, surgery may be necessary. The most common surgical procedures for intervertebral disc degeneration include discectomy, laminectomy, and spinal fusion.

Alternative therapies: Alternative therapies like chiropractic care, [[acupuncture]], and [[massage]] may provide some relief from back pain. However, there is limited scientific evidence to support their [[effectiveness]].

===== Shape-memory collagen scaffold =====



Koo et al. used a [[rat tail nucleotomy model]] to develop mechanically stable collagen-[[cryogel]] and [[fibrillated collagen]] with shape-memory for use in [[minimally invasive surgery]] for effective treatment of IVDD. The collagen was loaded with [[hyaluronic acid]] (HA) into a rat tail nucleotomy model.

The shape-memory collagen structures exhibited outstanding [[chondrogenic]] activities, having completely similar physical properties to those of a typical shape-memory alginate construct in terms of water absorption, compressive properties, and shape-memorability behavior. The treatment of rat tail nucleotomy model with shape-memory collagen-cryogel/HA alleviated mechanical allodynia, maintained a higher concentration of water content, and preserved the disc structure by restoring the matrix proteins.

According to these results, the [[collagen]]-based structure could effectively repair and maintain the [[Intervertebral disc]] [[matrix]] better than the controls, including [[hyaluronic acid]] only and shape-memory alginate with [[hyaluronic acid]]
((Koo YW, Lim CS, Darai A, Lee J, Kim W, Han I, Kim GH. Shape-memory collagen scaffold combined with hyaluronic acid for repairing [[intervertebral disc]]. Biomater Res. 2023 Mar 29;27(1):26. doi: 10.1186/s40824-023-00368-9. PMID: 36991502.)).

===== Discogenic pain treatment =====


see [[Discogenic pain treatment]].